Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS
نویسندگان
چکیده
منابع مشابه
Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS
Apical dendrites of Betz cells are important sites for the integration of cortical input, however their health has not been fully assessed in ALS patients. We investigated the primary motor cortices isolated from post-mortem normal control subjects, patients with familial ALS (fALS), sporadic ALS (sALS), ALS with frontotemporal dementia (FTD-ALS), and Alzheimer's disease (AD), and found profoun...
متن کاملThe cellular basis of dendrite pathology in neurodegenerative diseases
One of the characteristics of the neurons that distinguishes them from other cells is their complex and polarized structure consisting of dendrites, cell body, and axon. The complexity and diversity of dendrites are particularly well recognized, and accumulating evidences suggest that the alterations in the dendrite structure are associated with many neurodegenerative diseases. Given the import...
متن کاملA Novel Approach for Detecting Relationships in Social Networks Using Cellular Automata Based Graph Coloring
All the social networks can be modeled as a graph, where each roles as vertex and each relationroles as an edge. The graph can be show as G = [V;E], where V is the set of vertices and E is theset of edges. All social networks can be segmented to K groups, where there are members in eachgroup with same features. In each group each person knows other individuals and is in touch ...
متن کاملGenes Required for Wallerian Degeneration Also Govern Dendrite Degeneration: A Dissertation
Neurons comprise the main information processing cells of the nervous system. To integrate and transmit information, neurons elaborate dendritic structures to receive input and axons to relay that information to other cells. Due to their intricate structures, dendrites and axons are susceptible to damage whether by physical means or via disease mechanisms. Studying responses to axon injury, cal...
متن کاملDendrite pathology and neurodegeneration: focus on mTOR
Dendrites are exquisitely specialized cellular compartments that critically influence how neurons receive and process information. Most synaptic inputs are received onto dendritic shafts, or small protuberances known as dendritic spines, and are then integrated and transmitted to the cell soma. During nervous system development, dendrites are dynamic, expanding and retracting rapidly, in respon...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/srep41765